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bioRxiv 2024.10.25.620374; doi: https://doi.org/10.1101/2024.10.25.620374

PMCID: PMC11565995

Cholesterol binding to VCAM-1 promotes vascular inflammation.

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bioRxiv 2024.09.17.613543; doi: https://doi.org/10.1101/2024.09.17.613543.

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T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption.

Gao Y*, Kennelly JP*, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young S, Bensinger SJ, Tontonoz P.

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Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity.

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J Clin Invest. 2024 Jan 4:e173002.

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Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.

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Science.2023 Nov 10;382(6671):eadf0966.

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Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity.

Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY.

Sci Immunol. 2023 Mar 10;8(81):eabo2003.

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Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.

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Nat Metab.2023 Jan;5(1):165-181.

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Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.

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Sci Immunol. 2022 Jan 21;7(67):eabk0182.

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Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.

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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility.

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Cell Rep. 2021 Mar 23;34(12):108891.

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Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

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Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.

Gao Y, Deason K, Jain A, Irizarry-Caro RA, Dozmorov I, Coughlin LA, Rauch I, Evers BM, Koh AY, Wakeland EK, Pasare C.

J Exp Med. 2020 Apr 6;217(4):e20190476.

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MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage.

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Infect Immun. 2018 Apr 23;86(5):e00791-17.

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Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus.

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Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.

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